Melanoma is a type of skin cancer originating from the pigment producing cells in the skin called melanocytes. Though not as common as basal cell carcinoma and squamous cell carcinoma, it is more deadly because of its ability to spread to other parts of the body. Melanomas can have various appearances. The ABCDEs and Ugly Duckling Sign are two commonly used methods to help identify melanomas. The ABCDEs is a mnemonic used to remember warning signs for melanoma: A for Asymmetry, B for Borders being uneven or irregular, C for Color variation, D for Diameter >6mm, and E for Evolving or changing lesion. The Ugly Duckling Sign is another common method used to identify concerning lesions. It is based on the concept that normal moles on an individual are likely to be similar in appearance. Any lesion or growth that appears different or stands out like an “ugly duckling” warrants further evaluation. As early detection and treatment are crucial for improving survival, any new, unusual, changing, or symptomatic growth should prompt a visit to your dermatologist.